Johns Hopkins Medicine
The Peripheral Nerve Center at Johns Hopkins has assembled a group of specialists that provide expertise in most nerve disorders, including diagnosis and both medical and surgical treatments.
The Center was founded to provide the highest quality care for peripheral nerve diseases, including surgical options, and to generate new understanding of the diagnosis and treatment of nerve diseases through research.
The goals of the Peripheral Nerve Center at Johns Hopkins University are to develop new therapies that will reverse peripheral neuropathies by preventing axonal degeneration and restoring function to patients with sensory neuropathies; develop novel diagnostic strategies, or biomarkers, to more accurately and sensitively diagnose, track and monitor therapy for sensory neuropathies; a special emphasis on identifying underlying etiologies of painful peripheral neuropathies that are largely classified as “idiopathic;” and provide a collaborative training environment for neuroscientists committed to neuropathy research to facilitate care development and skill acquisition.
To these ends, the Foundation has dedicated funds to assist the Center with the expansion of a variety of initiatives. In order to speed the pace at which clinical trials may be conducted, the Foundation has promised funds to develop dedicated clinical trial infrastructure specific for peripheral neuropathy research.
The foundation has supported the screening and animal modeling of existing drugs for treatment of peripheral neuropathy and the regeneration of lost nerve cells, and the examination of the role of supporting cell changes in chronic peripheral neuropathies.
the research results, additional funding has been provided to Johns Hopkins to continue their research on the four compounds identified in their initial studies.
Update on FPN funded research at Johns Hopkins
Peripheral nerve regeneration in humans is suboptimal despite many years of research on various treatments demonstrating remarkable efficacy in animal models.
This is partly due to the fact that human nerves are much longer, and even though the peripheral axons can regenerate, Schwann cells, their glial cell partners in peripheral nerves, atrophy and do support regeneration with chronic denervation (reviewed in (Hoke, 2006)).
This proposal aims to build on our previous cycle of funding and evaluate a group of genes we have identified in denervated Schwann cells. We will examine their relevance to Schwann cell atrophy and lack of support for PNS regeneration.
We will utilize the knowledge gained from these studies in parallel with other projects in the lab that identified small molecule drugs that enhance the rate of axon outgrowth in sensory neurons.
The primary focus of the lab is to enhance peripheral nerve regeneration through both increasing the intrinsic capacity of axons to regenerate and the extrinsic influence of Schwann cells.
Specific aims of the proposal are:
To validate the role of various transcription factors, cell cycle genes and cell death pathway genes in maintenance of Schwann cells during chronic denervation. Specifically, we will test whether manipulation of these genes (upregulation or downregulation) will have an impact on Schwann cell apoptosis in vitro.
Hypotheses to be tested:
- Downregulation of cell death pathway genes upregulated during late stages of chronic denervation will prevent Schwann cell atrophy and death
- Upregulation of transcription factors downregulated during late stages of chronic denervation will prevent Schwann cell atrophy and death
Published updates: ILARJ; ANA2014
FPN Peripheral Neuropathy Research Registry
Collaborative efforts between our partners and other institutions help us work toward a greater understanding of the cause and progression of PN.
The Foundation is proud to provide the financial investments required to lead new medical innovations into the future.
In addtion to other funding provided to Johns Hopkins, The Foundation has awarded a grant for them to participate in FPN’s groundbreaking patient registry for people with painful and non-painful neuropathies.
Learn more about FPN Peripheral Neuropathy Research Registry
10 Fun Facts about Johns Hopkins University
September 17, 2018
Quaker connections, mutant rabbit rumors, schizophrenic literary legends… Johns Hopkins has a long and storied past! Here are 10 fun facts from Johns Hopkins’ 140 years of existence that even current students don’t know!
1. The S in Johns
Students can’t help but wince when outsiders call their beloved college “John Hopkins”… “There’s an S there: Johnsss Hopkins!” The school was named after the 18th-century Quaker entrepreneur and philanthropist Johns Hopkins.
He was named after his great-grandmother: Margaret Johns. Upon his death in 1873, the childless Johns Hopkins left $7M to found a university and hospital in his (somewhat confusing) name.
The donation broke records as the largest philanthropic gift in U.S. history.
2. Peabody Ties
America’s first academy of music, the Peabody Institute, became part of Johns Hopkins in 1985. It’s a conservatory that caters to musicians of all levels: beginners to Doctorate of Musical Arts. All can enjoy the beautifully designed Peabody Library.
3. Steam Tunnels
There’s a steam tunnel system under Johns Hopkins’ Homewood and East Baltimore campus (entrances can be found under buildings by Merrick Barn). In the 1990s, a rumor circulated that mutant rabbits occupied the tunnels under the physics building.
4. Presidential Glee
U.S. President Woodrow Wilson is a Hopkins alum. As a student, he sang “Star-Spangled Banner” with the university glee club; later, as president, made it the new national anthem. However, his time at Johns Hopkins was not particularly gleeful because of chronic migraines. He once told a classmate: “I came here to admire and have remained to scoff.”
5. Lacrosse Pride
Lacrosse is the most popular sport at Johns Hopkins – even homecoming is in the spring instead of in the fall for football. The team first competed in 1904. They represented the U.S.
in the 1932 Summer Olympics (pictured above). They’ve also won 44 national championships, including 9 NCAA Division 1 titles.
In 2015, they joined the newly-formulated Big Ten for lacrosse, and won the inaugural Big Ten championship against Ohio State Buckeyes.
6. First Research University
Johns Hopkins is the first research university in the United States. The school’s first president, Daniel Coit Gilman took the idea of merging teaching and research from the German education model of Alexander von Humboldt. Gilman argued “The best teachers are usually those who are free, competent and willing to make original researches in the library and the laboratory.”
7. Famous Alums
Famous alums of Johns Hopkins include Wolf Blitzer, Wes Craven, Tori Amos, and John Astin – famous for playing Gomez Addams, he returned to Johns Hopkins in 2005 as a professor… Oh and Johns Hopkins has 22 Nobel Laureates!
8. The Fitzgeralds
In 1932, F. Scott Fitzgerald took up residence across the street from Johns Hopkins University while his wife was patient at the university’s hospital (she was treated for schizophrenia). While in Baltimore, Zelda wrote her autobiographical novel “Save Me the Waltz” and F. Scott wrote “Tender Is the Night.”
9. From Humor to Mascot
The Johns Hopkins Blue Jays are the only mascot derived from a humor magazine. The “Black and Blue Jay” was a satirical student publication founded in the 1920s. After the magazine became popular, local newspapers stopped referring to Hopkins athletes as “the Black and Blue” and started calling them Blue Jays.
10. Bloomberg Billion
Michael Bloomberg attended Johns Hopkins in the 1960s, where he designed and built the school’s blue jay costume. He also served as the mascot at various lacrosse games. Never losing his school spirit, Bloomberg has donated over $1billion to Johns Hopkins over the past 40 years.
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