Viscosupplementation Treatment for Arthritis

What Are Viscosupplement Injections?

Viscosupplementation Treatment for Arthritis | Johns Hopkins Medicine

Treating knee arthritis is a step-by-step process. Conservative, non-invasive treatment options are always tried first: rest, ice, activity/lifestyle modification, and medications are usually enough to reduce the symptoms of mild to moderate arthritis. But, when they’re not, minimally invasive treatments are available and widely used. One such treatment option is viscosupplementation.

Viscosupplements: What They Are

Viscosupplements contain hyaluronic acid—a natural substance found in the synovial fluid that surrounds and lubricates the knee joint.

During viscosupplementation, the supplements, which come in a gel- fluid, are administered via injection into the knee joint.

Because patients with knee arthritis have a lower-than-normal concentration of hyaluronic acid in their joint(s), viscosupplementation can increase their knee joint mobility and decrease their arthritis-related symptoms, such as stiffness and pain.

Illustration 1- Knee anatomy. Synovial fluid lubricates the joint.

Viscosupplements: What They Aren’t

Viscosupplements can help patients with knee arthritis, but they can neither cure the condition nor regrow torn/lost cartilage. In fact, no current treatment option can—arthritis is a chronic condition. The goal when treating is to slow the progression and decreasing/eliminating its presenting symptoms.

How Viscosupplements Are Used

Viscosupplements are usually used as part of a complete arthritis treatment plan prescribed by an orthopedic specialist. Some other treatment options that might be used in conjunction with viscosupplements are:

  1. Physical therapy. Increasing the range of motion and strength increases joint mobility.
  2. Nonsteroidal anti-inflammatory drugs decrease inflammation and pain.
  3. Knee braces may help keep the joint aligned and ensure it moves properly.

The supplements are administered once-a-week for a period of three to five weeks depending on the type of viscosupplementation regiment used. Following the last injection, they can be given again after six months.

Seeking Treatment

Orthopedic specialists are the most trained and qualified medical professionals to treat knee arthritis. Their understanding of the condition and experience treating it helps them create appropriate and effective treatment plans, that may include viscosupplementation.  Dr.

Nicholas Alexander is the founder of Mahwah Valley Orthopedic Associates and a Board Certified Orthopedic Surgeon specializing in both the surgical and non-surgical treatment of hip and knee conditions.  Dr.

Alexander completed his Fellowship in Adult Reconstruction and Reconstructive Surgery of the Hip and Knee at the Johns Hopkins School of Medicine and has over two decades of experience. He also serves as the Chairman of the Valley Hospital Total Joint Center. 

If you suffer from knee arthritis and haven’t found a solution, please don’t hesitate to contact our office to arrange an appointment.   We will provide you with the solution you’ve been looking for—the road to a normal, pain-free life starts when you walk through our doors.


Knee injections or knee replacement: What are my options?

Viscosupplementation Treatment for Arthritis | Johns Hopkins Medicine

Osteoarthritis is a degenerative joint disease that can cause problems with the knees. Treatments for this include injections into the knee and replacing tissue in the knee. Which is best for treating osteoarthritis?

The condition often affects people aged 50 years and older, although it can also occur in younger people. According to the Arthritis Foundation, over 50 million people in the United States have arthritis.

Osteoarthritis (OA) is a chronic condition that causes the breakdown of cartilage between the joints. Cartilage serves as a cushion for joints and protects the surface of the bones. Without this cushion, bones can rub or grind together, causing pain, stiffness, and swelling.

If a patient continues to experience discomfort, swelling, or extensive joint damage, their doctor may suggest knee replacement or a knee injection.

Doctors will typically recommend knee injection therapy before recommending surgery. For some people, injections help to alleviate knee pain.

Corticosteroid injections

Corticosteroid injections are among the most common knee injections. Doctors inject corticosteroids directly into the knee joint to help relieve knee pain and inflammation quickly.

They are a class of medications related to the steroid cortisone. They are routinely used to reduce inflammation. Corticosteroids mimic the effects of a substance called cortisol that is naturally produced by the adrenal glands.

In high doses, corticosteroids can reduce inflammation. They also effect the immune system. This can be helpful for controlling conditions in which the immune system mistakenly attacks its own tissues, such as rheumatoid arthritis.

The corticosteroid is absorbed into the bloodstream quickly and travels to the inflammation site. Injection therapy provides rapid relief to the inflamed area and is more powerful than traditional oral anti-inflammatory medications.

In addition to providing quick relief, the injection does not cause many of the side effects that oral corticosteroid medications do.

Doctors can administer the injection in their office. They may numb the knee area before injecting the corticosteroid drug directly into the joint. Some people feel almost immediate relief, while others feel the effects several days later.

Depending on the condition of the knee, the benefits can last from a few days to more than 6 months. Factors that play a role in how long the effects of the steroid injection will last such as the extent of inflammation and overall health. It is important to note that the effects of the shot are temporary.

Additional cortisone injections may be necessary.

Many people have no adverse effects after a steroid injection besides a little pain or tingling where the injection was made. However, corticosteroids can cause dangerous side effects for some people, especially when taken too often.

Side effects include:

  • the death of nearby bone, known as osteonecrosis
  • joint infection
  • nerve damage
  • thinning of the skin and soft tissue around the injection site
  • a temporary flare of pain and inflammation in the joint
  • the thinning of nearby bone, known as osteoporosis
  • whitening or lightening of the skin around the injection site
  • diabetic patients can experience elevated blood sugar
  • allergic reaction

Exposure to high levels of cortisol over a prolonged period of time increases the risk of developing hypercortisolism or Cushing’s syndrome.

These effects include:

  • upper body obesity
  • a round-shaped face
  • increased bruising
  • trouble healing
  • weak bones
  • excessive hair growth
  • irregular menstrual periods in women
  • fertility problems in men

This side effect is treated by gradually reducing the amount of cortisone used or adjusting dosage.

Other injections

Some people have tried platelet-rich plasma or stem cell injections, but both the American College of Rheumatology and the Arthritis Foundation advise against using these treatments.

There is no standard procedure for either approach, and a person will not know exactly what is in their injection. Also, there is not enough evidence to show that these options are safe or effective.

Though corticosteroid control pain and inflammation efficiently, it only provides temporary relief. As OA progresses, mobility and quality of life may get worse, leaving a knee replacement as the only option.

A doctor will ly recommend knee replacement surgery once all other treatment options such as physical therapy and injections have been tried.

A knee replacement is also referred to as knee arthroplasty or knee resurfacing, because only the surface of the bones is replaced. The surgeon will cut away damaged bone and cartilage from the shinbone and kneecap, and then replace it with an artificial joint.

During a total knee replacement, the damaged knee joint is removed and replaced with a prosthesis made metal, ceramic, or high-grade plastic, as well as polymer components.

There are four basic steps:

  • Preparing the bone: The cartilage surfaces that are found at the end of the femur and tibia are removed along with a small amount of underlying bone.
  • Positioning the metal implants: The removed cartilage and bone are then replaced with metal components to recreate the surface of the joint. The metal parts are either cemented or “fit” into the bone.
  • Resurfacing the patella: The undersurface of the patella, or kneecap, may be cut and resurfaced with a plastic button.
  • Inserting a spacer: The surgeon inserts a medical-grade plastic between the metal components to create a smooth gliding surface, making walking easier and smoother.

Before the procedure, patients will work alongside doctors to design their artificial knee. A range of factors is taken into account, such as age, weight, activity levels, and overall health.

Delaying your surgery

There are risks associated with delaying knee replacement surgery. The main risks are further deterioration of the joint, increased pain, and reduced mobility.

Other risk factors include:

  • a risk of deformities developing inside and outside the joint
  • a risk of muscles, ligaments, and other structures becoming weak and losing function
  • increased pain or an inability to manage pain
  • increased disability or lack of mobility
  • difficulty with normal daily activities

The doctor will thoroughly explain the procedure and allow the patient to ask questions as needed. They will record a medical history, including any medications or supplements currently being taken, also taking allergies and previous health problems into account.

The doctor will give the individual general anesthesia before the surgery, making them completely unconscious. Patients often begin physical therapy to get the new joint moving during a short hospital stay. Rehabilitation continues after leaving the hospital. This can help regain strength and range of motion.

Knee replacement risks

Though knee replacement surgery often goes smoothly, any surgery comes with risks.

These include:

  • infection
  • blood clots in the leg vein or lungs
  • heart attack
  • stroke
  • nerve damage

If surgery is postponed for too long, other risks may arise. Deformities may develop that complicate the knee replacement procedure. Surgery may take longer, and knee replacement options may be limited.

Learn more about the causes of severe knee pain here.