- Skin Care Products in Monroe, LA
- About Professional Skin Care Products
- Hopkins Dermatology Exclusive Rx: Skincare Collection
- How Much Do Professional Skin Care Products Cost in Monroe, LA?
- What Are the Benefits of Professional Skin Care Products?
- How Do Professional Skin Care Products Work?
- What Should I Expect from Professional Skin Care Products?
- Be Healthy, Be Beautiful. Contact Hopkins Dermatology Today
- Lupus-Specific Skin Disease and Skin Problems
- Lupus-Specific Skin Disease
- Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE)
- Subacute Cutaneous Lupus Erythematosus (SCLE)
- Acute Cutaneous Lupus Erythematosus (ACLE)
- Malar Rash
- Livedo reticularis
- Oral and Nasal Ulcers
- Raynaud’s Phenomenon
- Hives (Urticaria)
- Cutaneous Vasculitis
- Touching a nerve: How every hair in skin feels touch and how it all gets to the brain
- In Third-Degree Burn Treatment, Hydrogel Helps Grow New, Scar-Free Skin
- Johns Hopkins University Archives
- Dr. Luis Garza Recent Interview
- Toll- Receptor 3 and Double-stranded RNA
- Successful Hair Growth in Mice and Rats
- Two New Hair Loss Cures in Mice in July 2018
- Mitochondrial Repair and Hair Growth
- Reversal of Fatty Diet Associated Hair Loss and Hair Whitening
- Side Effects
- Weight Gain
- Glucose Intolerance
- Increased Susceptibility to Infections
- Bone Thinning (Osteoporosis)
- Easy Bruising
- Mood Swings/Insomnia
- Avascular Necrosis of Bone
- Abdominal Striae
Skin Care Products in Monroe, LA
Your skin relies on key nutrients to stay vibrant and beautiful, and your skin care products are an important part of that process.
No professional aesthetic treatment in the world truly helps your skin if you use low-quality skin care. Dr. Janine Hopkins, M.D., F.A.A.D.
, board-certified dermatologist, offers professional skin care products for men and women in Monroe, Shreveport, the Ark-La-Miss and the surrounding areas of Northeast Louisiana.
About Professional Skin Care Products
Have you tried every product available on the market to improve the tone and texture of your skin? The products that you buy in the store rarely do as promised, and the reason is that the formulations do not contain the right ingredients. As a board-certified dermatologist, Dr. Hopkins understands skin, and she offers professional, high-quality skin care products for both men and women. We carry the following professional-grade skin care products at Hopkins Dermatology:
Hopkins Dermatology Exclusive Rx: Skincare Collection
Dr. Janine Hopkins and her team of professionals have curated an advanced skin care line to help her patients overcome their most frustrating skin care issues and anti-aging concerns.
From acne and hyperpigmentation to sun protection and discoloration, Dr. Hopkins and her team can recommend you with the lotion, serum or cream that will make all the difference in your skin.
Product order request now available online!
For more than a decade, SkinMedica® has provided professional-grade products that are formulated to cleanse, tone, brighten and rejuvenate your skin. As one of the leaders in the skin care industry, there is a proven SkinMedica® product for just about every skin concern.
Revision® has created some of the most significant innovations in skin care during the last 20 years. Some most popular products include the Nectifirm® cream and D-E-J Eye Cream® – but there is so much more. An expert on our team can connect you with the ideal Revision® products for your unique skin type.
Caudalie provides natural skin care and anti-aging treatments for all skin types. As a company, their commitment to your skin is as strong as it is to our community.
They donate a percentage of their profits to NPOs that protect the environment.
Using all-natural ingredients water, milk and oil, this skin care line is ideal for those with sensitive skin or for men and women looking for a natural approach.
How Much Do Professional Skin Care Products Cost in Monroe, LA?
Compared to the products that you buy in department stores, our professional skin care products are very affordable. Using less of the professional products to achieve exceptional results.
What Are the Benefits of Professional Skin Care Products?
- Safe for all skin types
- Improves skin health from the inside
- Easily fit into your schedule and lifestyle
- Appropriate for all life stages
- Saves money and time
- All natural ingredients
How Do Professional Skin Care Products Work?
Dr. Hopkins recommends skin care products based upon your skin type and any conditions that you experience, such as acne, rosacea, enlarged pores, and wrinkles.
She also considers how much time you spend in the sun and other lifestyle patterns. After you choose your skin care products, Dr. Hopkins explains how to use the products.
She may recommend a follow-up appointment to evaluate your progress.
What Should I Expect from Professional Skin Care Products?
many things in life, improving skin health takes time. You may notice an increase in blemishes, and this is normal, as it demonstrates that your pores are being cleansed from the inside. We recommend that you continue using the products as directed for at least two months. If you notice any irritation, contact us to schedule an appointment with Dr. Hopkins.
Be Healthy, Be Beautiful. Contact Hopkins Dermatology Today
Professional skin care products are great complements to your skin rejuvenation and anti-aging treatments at Hopkins Dermatology. As a board-certified dermatologist, Dr. Janine Hopkins, M.D., F.
A.A.D. offers professional skin care products for men and women in Monroe, Shreveport, the Ark-La-Miss and the surrounding areas of Northeast Louisiana. Contact us today to schedule an appointment.
Lupus-Specific Skin Disease and Skin Problems
Most people with lupus experience some sort of skin involvement during the course of their disease. In fact, skin conditions comprise 4 of the 11 criteria used by the American College of Rheumatology for classifying lupus. There are three major types of skin disease specific to lupus and various other non-specific skin manifestautions associated with the disease.
Lupus-Specific Skin Disease
Three forms of specific skin disease occur in people with lupus, and it is possible to have lesions of multiple types.
In addition, a person can also have one of the three forms outlined below without actually having full-blown systemic lupus erythematosus (SLE), but the presence of one of these disease forms may increase a person’s risk of developing SLE later in life.
Usually, a skin biopsy is used to diagnose forms of cutaneous lupus, and various medications are available for treatment, including steroid ointments, corticosteroids (e.g., prednisone), and antimalarials (e.g., Plaquenil).
Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE)
Chronic cutaneous (discoid) lupus erythematosus is usually diagnosed when someone exhibits signs of lupus in the skin. People with SLE can also have discoid lesions, and about 5% of all people with DLE will develop SLE later in life.
A skin biopsy is used to diagnose this condition, and the lesions have a characteristic pattern known to clinicians: they are thick and scaly, plug the hair follicles, appear usually on surfaces of the skin exposed to sun (but can occur in non-exposed areas), tend to scar, and usually do not itch.
If you are diagnosed with discoid lupus, you should try to avoid sun exposure when possible and wear sunscreen with Helioplex and an SPF of 70 or higher. In addition, you doctor may prescribe medications to help prevent and curb inflammation, including steroid ointments, pills, or injections , antimalarial medications such as Plaquenil, and/or immunosuppressive medications.
Subacute Cutaneous Lupus Erythematosus (SCLE)
About 10% of lupus patients have SCLE. The lesions characteristic of this condition usually do not scar, do not appear thick and scaly, and usually do not itch. About half of all people with SCLE will also fulfill the criteria for systemic lupus.
Treatment can be tricky because SCLE lesions often resist treatments with steroid creams and antimalarials.
People with SCLE should be sure to put on sunscreen and protective clothing when going outdoors in order to avoid sun exposure, which may trigger the development of more lesions.
Acute Cutaneous Lupus Erythematosus (ACLE)
Most people with ACLE have active SLE with skin inflammation, and ACLE lesions are found in about half of all people with SLE at some point during the course of the disease.
The lesions characteristic of ACLE usually occur in areas exposed to the sun and can be triggered by sun exposure.
Therefore, it is very important that people with ACLE wear sunscreen and protective clothing when going outdoors.
About half of all lupus patients experience a characteristic rash called the malar or “butterfly” rash that may occur spontaneously or after exposure to the sun. This rash is so-named because it resembles a butterfly, spanning the width of the face and covering both cheeks and the bridge of the nose.
The malar rash appears red, elevated, and sometimes scaly and can be distinguished from other rashes because it spares the nasal folds (the spaces just under each side of your nose). The butterfly rash may appear on its own, but some people observe that the appearance of the malar rash indicates an oncoming disease flare.
Whatever the case, it is important to pay attention to your body’s signals and notify your physician of anything unusual.
50% of all people with lupus experience sensitivity to sunlight and other sources of UV radiation, including artificial lighting. For many people, sun exposure causes exaggerated sunburn- reactions and skin rashes, yet sunlight can precipitate lupus flares involving other parts of the body. For this reason, sun protection is very important for people with lupus.
Since both UV-A and UV-B rays are known to cause activation of lupus, patients should wear sunscreen containing Helioplex and an SPF of 70 or higher. Sunscreen should be applied everywhere, including areas of your skin covered by clothing, since most clothing items contain an SPF of only about 5.
Be sure to reapply as directed on the bottle, since sweat and prolonged exposure can cause coverage to dissipate.
People with lupus may experience a lacy pattern under the skin called livedo reticularis. This pattern may range anywhere from a violet web just under the surface of the skin to something that looks a reddish stain.
Livedo can also be seen in babies and young women, is more prominent on the extremities, and is often accentuated by cold exposure.
The presence of livedo is usually not a cause for alarm, but it can be associated with antiphospholipid antibodies.
About 70% of people with lupus will experience hair loss (alopecia) at some point during the course of the disease. Hair loss in lupus is usually characterized by dry, brittle hair that breaks, and hair loss is more common around the top of the forehead. Physical and mental stress can also cause hair loss, as can certain medications, including corticosteroids such as prednisone.
In many cases the hair will grow back, but hair loss due to scarring from discoid skin lesions may be permanent. There is no cure-all for hair loss, but treatments such as topical steroids and Rogaine may be prescribed. Sometimes dealing with the cosmetic side effects of lupus can be difficult, but some people find using hairpieces and wigs to be an effective means of disguising hair loss.
Oral and Nasal Ulcers
About 25% of people with lupus experience lesions that affect the mouth, nose, and sometimes even the eyes. These lesions may feel small ulcers or “canker sores.
” Such sores are not dangerous but can be uncomfortable if not treated.
If you experience these types of lesions, your doctor may give you special mouthwash or Kenalog in Orabase (triamcinolone dental paste) to help expedite the healing process.
Approximately one-third of all people with lupus experience a condition called Raynaud’s phenomenon in which the blood vessels supplying the fingers and toes constrict. The digits of people with Raynaud’s are especially susceptible to cold temperatures.
Often people with the condition will experience a blanching (loss of color) in the digits, followed by blue, then red discoloration in temperatures that would only be mildly uncomfortable to other people (such as a highly air-conditioned room).
It is very important that people with Raynaud’s wear gloves and socks when in air-conditioned spaces or outside in cool weather. Hand warmers used for winter sports (e.g., Hot Hands) can also be purchased and kept in your pockets to keep your hands warm.
These measures are very important, since Raynaud’s phenomenon can cause ulceration and even tissue death of the fingers and toes if precautions are not taken. People have even lost the ends of their fingers and toes due to the poor circulation involved in Raynaud’s phenomenon.
Cigarettes and caffeine can exacerbate the effects of Raynaud’s, so be sure to avoid these substances. If needed, your doctor may also recommend a calcium channel blocker medication such as nifedipine or amlodipine to help dilate your blood vessels.
About 10% of all people with lupus will experience hives (urticaria). These lesions usually itch, and even though people often experience hives due to allergic reactions, hives lasting more than 24 hours are ly due to lupus.
If you experience this condition, be sure to speak with your doctor, since s/he will want to be sure that the lesions are not caused by some other underlying condition, such as vasculitis or a reaction to medication.
Your doctor will probably distinguish these lesions from those caused by vasculitis by touching them to see if they blanch (turn white).
Approximately 15% of people with lupus will experience purpura (small red or purple discolorations caused by leaking of blood vessels just underneath the skin) during the course of the disease. Small purpura spots are called petechiae, and larger spots are called eccymoses. Purpura may indicate insufficient blood platelet levels, effects of medications, and other conditions.
Some people with lupus may develop a condition known as cutaneous vasculitis, in which the blood vessels near the skin experience inflammation that ultimately restricts blood flow. This condition can cause hive- lesions on the skin that may itch and do not turn white when depressed.
Other skin abnormalities may also be present, including actual gangrene of the digits. If left untreated, vasculitic lesions may cause ulceration and necrosis (cell death), and dead tissue must be surgically removed. Rarely, fingers or toes with aggressive ulceration and gangrene may require amputation.
Therefore, it is very important that you notify your doctor of any skin abnormalities.
Touching a nerve: How every hair in skin feels touch and how it all gets to the brain
Neuroscientists at the Johns Hopkins University School of Medicine have discovered how the sense of touch is wired in the skin and nervous system. The new findings, published Dec. 22 in Cell, open new doors for understanding how the brain collects and processes information from hairy skin.
“You can deflect a single hair on your arm and feel it, but how can you tell the difference between a raindrop, a light breeze or a poke of a stick?” says David Ginty, Ph.D., professor of neuroscience at Johns Hopkins. “Touch is not yes or no; it's very rich, and now we're starting to understand how all those inputs are processed.”
Ginty and his colleagues study how the nervous system develops and is wired. In trying to understand how touch-responsive nerve cells develop, they set out to build new tools that enable them to look at individual nerve cells.
According to Ginty, there are more than 20 broad classes of so-called mechanosensory nerve cells in the skin — of which only six account for light touch — that sense everything from temperature to pain.
But until now, the only way to tell one cell from another was to take electrical recordings as each type of cell generates a different current what it senses.
The team first genetically engineered mice to make a fluorescent protein in one type of nerve cell — called the C-type low-threshold mechanosensory receptor or C-LTMR.
C-LTMR cells stretch from the spinal cord to the skin, and those cells containing fluorescent protein could be seen in their entirety under a microscope.
The team found that each C-LTMR cell branched to send projections to as many as 30 different hair follicles.
Mice have three different types of hair: a thick, long guard hair that accounts for only about 1 percent of total hairs on the body; a shorter hair called the awl/auchene that constitutes about 23 percent of body hair; and a fine hair called the zigzag that makes up 76 percent of body hair. The team found that most of the C-LTMR cell endings — about 80 percent — associate with zigzag hair follicles, the rest with the awl/auchene and none with the guard hair follicles.
The researchers then similarly marked two other types of touch nerve cells and found that each hair type has a different and specific set of nerve endings associated with it. “This makes every hair a unique mechanosensory organ,” says Ginty. Moreover, with their new marking tools, they found that each hair type is evenly spaced and patterned throughout the skin.
The team then wondered how all the input from these individual hairs is collected and sent to the brain. Using a different dying technique, the researchers were able to stain the other end of the cell, in the spinal cord.
They found that the nerves connecting each patch of skin containing one guard hair and other associated smaller hairs line up in columns in the spinal cord — neighboring columns correspond to neighboring patches of skin.
They estimate that there are about 3,000 to 5,000 columns in the spinal cord, with each column accounting for 100 to 150 hair follicles.
So how does the brain interpret what each hair follicle experiences? “How this happens is remarkable and we're fairly clueless about it,” says Ginty.
But he suspects that the organization of the columns is key to how all the various inputs are processed before a message goes to the brain. And while people are not as hairy as mice, Ginty believes that many of the same structures are shared.
This study and the new cell-marking tools they developed, he says, open a lot of doors for new research in understanding touch and other senses.
This study was funded by the National institutes of Health, the Johns Hopkins NINDS core imaging facility and the Howard Hughes Medical Institute.
Authors on the paper are Lishi Li, Michael Rutlin, Victoria Abraira, Wenqin Luo and David Ginty of Johns Hopkins; Colleen Cassidy and C. Jeffery Woodbury of University of Wyoming; Laura Kus, Shiaoching Gong and Nathaniel Heintz of the Howard Hughes Medical Institute and The Rockefeller University; and Michael Jankowski and H. Richard Koerber of University of Pittsburgh School of Medicine.
Materials provided by Johns Hopkins Medicine. Note: Content may be edited for style and length.
In Third-Degree Burn Treatment, Hydrogel Helps Grow New, Scar-Free Skin
Johns Hopkins researchers have developed a jelly- material and wound treatment method that, in early experiments on skin damaged by severe burns, appeared to regenerate healthy, scar-free tissue.
In the Dec. 12-16 online Early Edition of Proceedings of the National Academy of Sciences, the researchers reported their promising results from mouse tissue tests. The new treatment has not yet been tested on human patients.
But the researchers say the procedure, which promotes the formation of new blood vessels and skin, including hair follicles, could lead to greatly improved healing for injured soldiers, home fire victims and other people with third-degree burns.
In early testing, this hydrogel, developed by Johns Hopkins researchers, helped improve healing in third-degree burns. Photo by Will Kirk/HomewoodPhoto.jhu.edu
The treatment involved a simple wound dressing that included a specially designed hydrogel—a water-based, three-dimensional framework of polymers. This material was developed by researchers at Johns Hopkins’ Whiting School of Engineering, working with clinicians at the Johns Hopkins Bayview Medical Center Burn Center and the Department of Pathology at the university’s School of Medicine.
Third-degree burns typically destroy the top layers of skin down to the muscle. They require complex medical care and leave behind ugly scarring. But in the journal article, the Johns Hopkins team reported that their hydrogel method yielded better results.
“This treatment promoted the development of new blood vessels and the regeneration of complex layers of skin, including hair follicles and the glands that produce skin oil,” said Sharon Gerecht, an assistant professor of chemical and biomolecular engineering who was principal investigator on the study.
Gerecht said the hydrogel could form the basis of an inexpensive burn wound treatment that works better than currently available clinical therapies, adding that it would be easy to manufacture on a large scale.
Gerecht suggested that because the hydrogel contains no drugs or biological components to make it work, the Food and Drug Administration would most ly classify it as a device. Further animal testing is planned before trials on human patients begin.
But Gerecht said, “It could be approved for clinical use after just a few years of testing.”
John Harmon, a professor of surgery at the Johns Hopkins School of Medicine and director of surgical research at Bayview, described the mouse study results as “absolutely remarkable. We got complete skin regeneration, which never happens in typical burn wound treatment.”
Guoming Sun, left, a postdoctoral fellow, and Sharon Gerecht, an assistant professor of chemical and biomolecular engineering, helped develop a hydrogel that improved burn healing in early experiments. Photo by Will Kirk/HomewoodPhoto.jhu.edu
If the treatment succeeds in human patients, it could address a serious form of injury. Harmon, a coauthor of the PNAS journal article, pointed out that 100,000 third-degree burns are treated in U. S.
burn centers Bayview every year.
A burn wound dressing using the new hydrogel could have enormous potential for use in applications beyond common burns, including treatment of diabetic patients with foot ulcers, Harmon said.
Guoming Sun, Gerecht’s Maryland Stem Cell Research Postdoctoral Fellow and lead author on the paper, has been working with these hydrogels for the last three years, developing ways to improve the growth of blood vessels, a process called angiogenesis. “Our goal was to induce the growth of functional new blood vessels within the hydrogel to treat wounds and ischemic disease, which reduces blood flow to organs the heart,” Sun said. “These tests on burn injuries just proved its potential.”
Gerecht says the hydrogel is constructed in such a way that it allows tissue regeneration and blood vessel formation to occur very quickly.
“Inflammatory cells are able to easily penetrate and degrade the hydrogel, enabling blood vessels to fill in and support wound healing and the growth of new tissue,” she said.
For burns, the faster this process occurs, Gerecht added, the less there is a chance for scarring.
Originally, her team intended to load the gel with stem cells and infuse it with growth factors to trigger and direct the tissue development. Instead, they tested the gel alone. “We were surprised to see such complete regeneration in the absence of any added biological signals,” Gerecht said.
Sun added, “Complete skin regeneration is desired for various wound injuries. With further fine-tuning of these kinds of biomaterial frameworks, we may restore normal skin structures for other injuries such as skin ulcers.”
Gerecht and Harmon say they don’t fully understand how the hydrogel dressing is working. After it is applied, the tissue progresses through the various stages of wound repair, Gerecht said. After 21 days, the gel has been harmlessly absorbed, and the tissue continues to return to the appearance of normal skin.
The hydrogel is mainly made of water with dissolved dextran—a polysaccharide (sugar molecule chains). “It also could be that the physical structure of the hydrogel guides the repair,” Gerecht said.
Harmon speculates that the hydrogel may recruit circulating bone marrow stem cells in the bloodstream. Stem cells are special cells that can grow into practically any sort of tissue if provided with the right chemical cue.
“It’s possible the gel is somehow signaling the stem cells to become new skin and blood vessels,” Harmon said.
Additional co-authors of the study included Charles Steenbergen, a professor in the Department of Pathology; Karen Fox-Talbot, a senior research specialist from the Johns Hopkins School of Medicine; and physician researchers Xianjie Zhang, Raul Sebastian and Maura Reinblatt from the Department of Surgery and Hendrix Burn and Wound Lab. From the Whiting School’s Department of Chemical and Biomolecular Engineering, other co-authors were doctoral students Yu-I (Tom) Shen and Laura Dickinson, who is a Johns Hopkins Institute for NanoBioTechnology (INBT) National Science Foundation IGERT fellow. Gerecht is an affiliated faculty member of INBT.
The work was funded in part by the Maryland Stem Cell Research Fund Exploratory Grant and Postdoctoral Fellowship and the National Institutes of Health.
The Johns Hopkins Technology Transfer staff has filed a provisional patent application to protect the intellectual property involved in this project.
Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman.
Sharon Gerecht’s Lab: http://www.jhu.edu/chembe/gerecht/
Johns Hopkins Burn Center: http://www.hopkinsmedicine.org/burn/
Johns Hopkins Institute for NanoBioTechnology: http://inbt.jhu.edu/
Johns Hopkins University news releases can be found on the World Wide Web at http://www.jhu.edu/news_info/news/. Information on automatic E-mail delivery of science and medical news releases is available at the same address.
Johns Hopkins University Archives
Update: April 27, 2020
Dermatologist Dr. Luis Garza from John Hopkins Medicine is among the 10 most renowned hair loss researchers in the US. Both the general media and myself have not covered him anywhere near as frequently as we have others. Especially compared to the “Big Three” of Angela Christiano, George Cotsarelis and Ken Washenik.
However, as a hair loss researcher, I respect Dr. Garza more than any other leading scientist. Primarily because he seems to have stuck with one institution for most of his career. And he does not seem to be affiliated with various commercial interests. Dr. Garza is especially well known for his work with PGD2 and hair growth.
Dr. Luis Garza Recent Interview
Yesterday, I discovered a great recent video interview of Dr. Garza with ideaXme’s Ira Pastor. It only had 508 views at the time of writing this post, so was missed by most people. has a goldmine of such barely viewed content that does not show up when people sort by view count.
At the moment, the below video has 25 thumbs up votes and 0 thumbs down votes. I agree with this percentage. This is the first time that I have seen Dr. Garza on video, which is very surprising to me.
Among the most interesting parts of the below video include:
- Double-stranded RNA (dsRNA) and its influence on scarless wound healing and hair regeneration.
- Wounding and hair growth aka wound induced hair neogenesis.
- Genes involving dsRNA and genes involving skin retinoic acid production are both expressed at higher levels after laser treatment.
- Organogenesis and limb regeneration to help the wounded.
- The connection and similarities between hair regeneration, skin regeneration and organ regeneration.
- Cells have a GPS type homing mechanism that tells them where to go and how to behave.
August 6, 2015
I have discussed Dr. Luis Garza’s work on this blog several times before, mostly related to his important findings about prostaglandin D2 (PGD2) and its impact on hair growth. Dr.
Garza is among the most accomplished and respected hair loss researchers in the world. He works at the Johns Hopkins University School of Medicine. In fact he has his own named facility there called the Garza Laboratory.
The list of projects that his team is currently working on includes several focused on hair growth.
Toll- Receptor 3 and Double-stranded RNA
Today, Dr. Garza and his team published an important article in the Cell Stem Cell Journal. They have found that a protein called toll- receptor 3 (TLR3) plays a crucial role in the regeneration of damaged skin and hair follicles. TLR3 activates various genes (IL6 and STAT3) and signaling pathways (Wnt and Shh) that are involved in hair regeneration.
It is common knowledge that damaged mammalian skin releases double-stranded RNA (dsRNA), which is then sensed by TLR3. Besides the previously mentioned regeneration of damaged skin and hair follicles, TLR2 also plays a role in activating the immune system.
While most of the main work was done on mice, in a side experiment on humans, the Garza team found that “the expression of TLR3 was five times higher in scratched human skin cell samples compared to healthy skin cell samples.”
The Garza team also found that adding synthetic synthetic dsRNA to mouse skin wounds led to a greater number of regenerated follicles.
My two favorite quotes from Dr. Garza in the article:
It has long been known that skin damage can trigger regeneration.
The clinical translation of this work is promising because work has already started, says Garza. Drug companies are already developing products to activate TLR3 to trigger the immune system, and these same products could be tested to promote regeneration.
My least favorite quote from Dr. Garza in the article (although the “might” in there is encouraging):
He also made clear that the information might not be as applicable to conditions unrelated to scarring or to those whose hair follicles are lost from male pattern baldness.
Virtually all hair related research at universities, clinics and private labs starts with experimentation in mice or rats. Per the Foundation for Biomedical Research, 95 percent of all lab animals are mice and rats.
I am guessing that the smaller sized mice represent a much higher share of this 95 percent in comparison to the larger sized rats.
A hair loss cure is therefore all the more necessary in order to save the lives of millions of sacred rodents.
During my research for this post, I read that one of the main differences between mice and rats is that while the former are very curious, the latter are fairly cautious. i.e.
, the smaller rodent is braver (or more foolish) than the larger rodent. When I saw “Rats”, I did not find rats to be particularly cautious. According to that documentary, rats are the most successful species on earth.
They will surely outlast us, as will cockroaches.
Successful Hair Growth in Mice and Rats
Since I first started writing this blog, the single biggest pet peeve of most readers as well as myself has been:
Why is hair loss regularly cured in mice and other rodents, but never in humans?
Forget the word “cure”. Even a moderately effective hair loss treatment would be welcome. The countless groundbreaking successes in hair regrowth in mice over the past several decades have never even translated into any major hair loss treatment for humans. This travesty has been going on for way too long.
Dr. Tsuji’s Famous Mouse Growing Hair.
All we can do is hope than sooner or later, someone Dr. Tsuji will emulate his success in mice -> to success in humans -> to a final product release. In many cases, positive results in mice and then in small-scale human trials never progress to a final product release due to lack of funding or corporate interest.
However, this should change in the next several years as a number of companies start or complete final Phase 3 clinical human trials for various new hair growth products.
The main reasons researchers to use mice and rats for their hair loss research work are:
- Low cost.
- An abundant and plentiful supply.
- Small creature size making housing, feeding and maintenance relatively easy.
- Short 2-3 year lifespan making generational study possible.
- Mice and humans share about 97.5 percent of their working DNA. Almost as similar as the relationship between humans and the great apes.
Two New Hair Loss Cures in Mice in July 2018
Note: I am a bit uncertain if mouse or rat fur can be compared to human scalp hair more than to human body hair. In humans, scalp hair and body hair often have an inverse relationship.
Mitochondrial Repair and Hair Growth
As a result of the earlier mentioned pet peeve, I initially decided to ignore the biggest hair loss related news story of this month from several weeks ago. Scientists from the University of Alabama (led by Dr.
Keshav Singh) managed to reverse hair loss and skin wrinkling in mice. Actual study findings are here.
The scientists managed to reverse mitochondrial dysfunction (which they induced in the first place), which in turn reversed hair loss and wrinkling in mice.
Reversal of wrinkles and hair loss after mitochondrial DNA replication is resumed. Credit: University of Alabama.
This news was covered extensively by the global media.
I decided to skip writing about these findings, and instead focused on keeping my posts on the important recent developments from Histogen and Cassiopea on the front page of this blog a little longer.
Both of these companies are going to complete final Phase 3 trials in humans in the next several years. In contrast, The University of Alabama research might not even ever make it to Phase 1 trials in humans.
Reversal of Fatty Diet Associated Hair Loss and Hair Whitening
However, yesterday came news of yet another major development in regards to scientists curing hair loss in mice. So I finally had to write this post on rodents getting back their hair (and their hair color and their youthful skin) twice in the past two weeks. It is ironic that rodents do not even care one iota about their appearance, as far as I can tell.
Credit: Johns Hopkins University.
This time, the latest research was in regards to hair loss in mice that was associated with a bad “western” diet high in fat and cholesterol. Actual study findings are here. The cure entails daily ingestion of a pill that the mice will have to remember to take. The compound halts the production of certain types of fats known as glycosphingolipids (GSLs).
The research was undertaken by scientists at Johns Hopkins University (led by Dr. Subroto Chatterjee). One of the interesting quotes in relation to this work was that:
“Current research shows that mice fed a diet high in fat and cholesterol are more ly to have hair discoloration from black to gray to white, extensive hair loss and inflammation of skin exhibited by multiple wounds.”
Long-time readers of this blog will know that this link between bad diet and hair loss has often been blamed for increasing hair loss in Japanese men since the end of World War II. I think that men and women in all countries are losing hair at earlier ages than in past generations. I was never too keen about this diet and hair loss argument, but perhaps there is something to it?
Prednisone is a corticosteroid. In contrast to anabolic steroids (used by “bodybuilders”), corticosteroids are used in inflammatory conditions for their anti–inflammatory effects.
They have a rapid onset of action, and profoundly affect many parts of the immune system as well as most other body systems.
Corticosteroids are a cornerstone of treating most types of vasculitis, and are often used in combination with other immunosuppressive medications.
Many of the side–effects of steroids are predictable. All are related to: 1) the amount of steroid a patient takes in his/her daily dose, and 2) the length of time the patient remains on the medication. We emphasize that not all side–effects occur in all patients.
Despite the numerous potential side–effects of corticosteroids listed below, their introduction into patient care 50 years ago revolutionized the treatment of many diseases, including vasculitis. When used properly, these drugs save lives and avert threats to the function of important organs.
One of the numerous potential side–effects of prednisone and other forms of corticosteroid treatment is hirsutism — excessive growth of body hair. Patients vary in the degree to which this side–effect of steroids occurs.
Although some experience minimal hirsutism, the patient depicted here developed this side effect after taking 10 milligrams of prednisone for a few months.
Weight gain is usually the most dreaded side–effects of steroid use, incurred to some degree by nearly all patients who take them. The amount of weight gain varies from individual to individual.
In addition to causing weight gain, prednisone leads to a redistribution of body fat to places that are undesirable, particularly the face, back of the neck, and abdomen. Pictured below is a example of redistribution of body fat to the back of the neck.
Accumulation of fat in this area is sometimes referred to as a “buffalo hump”.
Another example of this “redistribution” is pictured below.
Supraclavical “fat pads” are collections of fat at the base of the neck, just above the collarbones, which are common in patients on steroids.
They sometimes cause concern among patients if mistaken for lymph nodes or other causes for worry, but will gradually subside as the prednisone dose is tapered to below 10 milligrams/day.
High blood sugar, or steroid–induced diabetes. This usually resolves when the steroids are decreased or discontinued.
High blood pressure. This usually improves as the corticosteroid dose is reduced.
Increased Susceptibility to Infections
Patients are at increased risk for many types of infections, from minor fungal infections in the mouth (“thrush”, caused by Candida) to life–threatening infections such as Pneumocystis carinii pneumonia.
The higher the steroid dose and the longer the duration of therapy, the greater the risk of infection. The risk is also increased when patients receive combinations of immunosuppressive medications, such as cyclophosphamide (cytoxan) and prednisone.
The risk of some infections can be greatly reduced by taking specific types of antibiotics prophylactically.
Pictured below is woman under treatment with prednisone and methotrexate for vasculitis and a concurrent neurologic condition (myasthenia gravis) developed painful vesicles in her mouth. The vesicles were confirmed by culture to be caused by re–activation of a Herpes simplex infection, and responded to treatment with acyclovir.
Bone Thinning (Osteoporosis)
Prednisone may cause thinning of the bones even in people who are not usually at high risk for osteoporosis (for example: males, young people).
In people susceptible to osteoporosis, prednisone may accelerate the process of bone loss. Fortunately, in the past few years, excellent treatments and preventive measures have become available for osteoporosis.
All patients on prednisone for prolonged periods are candidates for these medicines.
Prednisone also causes “thin skin”. Patients on moderate to high doses of prednisone often notice that they bruise easily, even with only slight trauma. Pictured below is a patient with giant cell arteritis who suffered a skin laceration after she struck her leg against a chair.
Many patients find it difficult to sleep when taking high doses of steroids. Many also find that they are more irritable than usual. Steroids sometimes even induce depression, which improves when the drug is decreased or discontinued.
Avascular Necrosis of Bone
For reasons that are not known, high dose prednisone (for example, greater than 20 milligrams a day) predisposes some patients to joint damage, most often of the hips.
In avascular necrosis (or osteonecrosis, meaning “bone death”) of the hip, the part of the leg bone that inserts into the pelvis dies, resulting in pain with weight–bearing and some loss of joint function.
Many patients with avascular necrosis require joint replacements.
Abdominal striae (“stripes”), as pictured below, frequently occur in patients who take high doses of steroids for long periods of time.
Long–term steroid use may lead to cataract development in the eyes, which frequently require surgical removal.
High dose prednisone predisposes some patients to acne, especially facial acne, as pictured below. The facial acne developed after several weeks of high steroid doses.